Research Associate, Disease Biology - South San Francisco
About Frontier Medicines
Frontier Medicines, located in South San Francisco, CA and Boston, MA, is a precision medicine company that has pioneered a powerful discovery and development platform designed to generate medicines against disease-causing proteins previously considered undruggable. We are deploying our technologies in chemoproteomics, covalent drug discovery, and machine learning to develop a pipeline of groundbreaking medicines against the most important drivers of disease. Frontier has been recognized as a Fierce 15 company and a C&EN Start-Up to Watch. Our lead program targets both the active and inactive forms of KRASG12C, a validated driver in a number of cancers that until recently has been undruggable. Our pipeline embodies our vision of boldly advancing science to defeat disease, starting with cancer.
About the Role
Frontier Medicines is seeking a highly motivated individual to fill the position of Research Associate in the Disease Biology team. The successful candidate is expected to have an excellent working knowledge of molecular and cell biology techniques in oncology research. This position requires working as part of a multidisciplinary team in a fast-paced drug-hunting environment.
- Design, execute, and analyze key biological experiments to define drug mechanism of action, develop novel disease models and biomarkers for target engagement and patient selection with independence and creativity.
- Contribute to target validation to ensure the development of a robust preclinical pipeline of impactful drug discovery programs.
- Contribute to project teams and the preclinical development of lead assets to achieve project deliverables.
- Effectively communicate with colleagues and stakeholders; create and present research updates and provide scientific input to team/company meetings.
- Coordinate with external contract research organizations and with other collaborators, as needed.
- Maintain a clear, detailed electronic laboratory notebook to document all experiments and findings.
- Comply with best laboratory safety practices.
- BSc or MSc in a biological science (biochemistry, molecular biology, cellular biology or related discipline).
- Mammalian cell culture experience and associated technologies (knockdown, over-expression studies).
- Experience with cellular and biochemical techniques such as western blotting, ELISA, immunoprecipitation and immunofluorescence/histochemistry.
- Excellent communication, organization, and technical writing skills.
- Strong problem-solving skills, ability to learn new skills.
- Legally authorized to work in the U.S.
- 3-5 years of relevant post-graduate and pharma/biotech experience.
- Experience in cancer biology, working in oncology drug discovery project teams, cancer cell-based assay design, assay development and drug testing.
- Demonstrated track record of accomplishments and publications in biology.