Director / Senior Director, Head of Protein Sciences – South San Francisco or Boston

About Frontier Medicines

Frontier Medicines, located in Boston, MA and South San Francisco, CA, is a precision medicine company that has pioneered a proprietary discovery and development platform to develop medicines against disease-causing proteins previously considered undruggable. We are deploying groundbreaking scientific approaches in chemoproteomics, covalent drug discovery, and machine learning to develop medicines, starting with anti-cancer therapies.  Frontier has prioritized a set of high-impact targets in the development of our pipeline. These programs embody our vision of developing precision medicines against important oncology targets that could bring meaningful benefit to patients.

About the Role

Frontier Medicines is seeking a highly motivated individual to fill the Head of Protein Sciences position to help build our protein sciences capabilities, contribute to both the development of our drug discovery platform and drive delivery of our therapeutic pipeline.  The team is focused on the discovery of new medicines to treat cancers and other serious disorders.  The successful candidate will implement systems and strategies to deliver the highest quality proteins to enable Frontier Medicines’ drug discovery platform and provide leadership within project teams. The position will report to the VP of Innovation and Discovery and can be located at either the Boston or South San Francisco site.

Key Responsibilities
  • Partner with colleagues in biochemistry and biophysics, chemical biology, disease biology, computational and medicinal chemistry and other functional groups to drive project progression
  • Build and lead protein sciences to deliver high quality targets to drive drug discovery and structurally enable project teams
  • Design and enable protein strategies across the portfolio of programs
  • Manage external CROs to ensure the delivery of high-quality proteins, efficient recombinant protein design, protein expression, protein purification
  • Efficiently accomplish project goals on time and budget
  • Stay scientifically current, and implement new technologies to enhance protein science capabilities
  • Make intellectual contributions to all stages of the drug discovery process and clearly articulate deliverables, progress, and issues to drug discovery teams
  • PhD in biochemistry, biophysics or other relevant degree and at least 12 years of relevant experience in the biotech or pharmaceutical industry
  • Experience in building and leading a protein science team is required
  • Possess in-depth, current knowledge expression construct design and optimization, protein production in bacterial, insect and mammalian cells, purification strategies and analytical protein chemistry
  • Experience balancing CRO and internal resources to solve problems and drive progress
  • Exceptional interpersonal and communication skills, and the ability to work seamlessly with multiple drug discovery teams and provide structure related support at all stages of the project
  • Demonstrated track record of success in structure-enabled drug discovery programs, as evidenced by a significant publication record in journals, patents and presentations
  • Strong interpersonal, influencing and collaboration skills to work in a team-oriented matrix environment, and the ability to work independently and effectively within tight timelines
  • Strong organizational skills; ability to manage multiple projects simultaneously and the capability to prioritize
  • Ability to work with independence and drive in a startup environment

To apply, please send your resume to